![]() 7 The pediatric study (in children eight to 17 years of age) found a significant reduction in pain but no significant change in other symptoms these findings are particularly important given the lack of effective treatment options for children with IBS. In the adult trial, 79 percent of treated patients experienced a reduction in the severity of abdominal pain, compared with 43 percent of control patients 83 percent had less abdominal distension, compared with 29 percent of control patients 83 percent had reduced stool frequency, compared with 32 percent of control patients and 79 percent experienced less f latulence, compared with 22 percent of control patients ( P <.05). Since the meta-analysis was performed, two additional trials-one in adults (n = 110) 7 and one in a pediatric population (n = 42) 8-have shown a modest but statistically significant benefit. Menthol, which is extracted from peppermint, is a common ingredient in over-the-counter topical products used for respiratory congestion, headache, and muscle pain. Extracts of peppermint are widely used as flavoring (rather than for their medicinal properties) in many products, including toothpastes, mouthwashes, and over-the-counter gastrointestinal (GI) products. ![]() Peppermint oil, which is extracted from the stem, leaves, and flowers of the plant, has become popular as a treatment for a variety of conditions, including irritable bowel syndrome (IBS), headache, and non-ulcer dyspepsia ( Table 1). The medicinal use of peppermint and other mint plants probably dates back to the herbal pharmacopoeia of ancient Greece, where peppermint leaf traditionally was used internally as a digestive aid and for management of gallbladder disease it also was used in inhaled form for upper respiratory symptoms and cough. Peppermint (Mentha x piperita) is a perennial flowering member of the mint family, which grows widely in Europe and North America.
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